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KMID : 0379520050210040361
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한국독성학회지
2005 Volume.21 No. 4 p.361 ~ p.365
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Single Oral Dose Toxicity Studies of Polycan, beta-Glucan Originated from Aureobasidium in Mice
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Lee Hyeung-Sik
Yang Kun-Ju
Shin Hyun-Dong
Park Bok-Ryeon
Son Chang-Woo
Jang Hee-Jeong
Park Dong-Chan
Jung Young-Mi
Ku Sae-Kwang
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Abstract
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This study was conducted to obtain the acute information of the oral dose toxicity of Polycan - originated from Aureobasidium pullulans SM-2001 (half of the dry material is -1,3/1,6-glucans), a UV induced mutant of A. pullulans, having various pharmacological effects, in male and female mice. In order to calculate 50% lethal dose (LD_{50}), approximate LD and target organs, test article was administered twice by oral gavage to male and female ICR mice at total 1000, 500 and 250mg/kg. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings. The results obtained in this study suggest that the Polycan is non-toxic in mice and is therefore likely to be safe for clinical use. The L050 and approximate (LD_{50}) in mice after single oral dose of Polycan were considered over 1000 mg/kg, respectively.
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KEYWORD
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Polycan, Single oral dose toxicity, Mice
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